Data Publication

Dataset - Nanoparticulated Bimodal Contrast Agent for Ultra-High-Field Magnetic Resonance Imaging and Spectral X-ray Computed Tomography

DIGITAL.CSIC

(2024)

Descriptions

Bimodal medical imaging based on Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) is a well-known strategy to increase diagnostic accuracy. The most recent advances in MRI and CT instrumentation are related to the use of ultrahigh magnetic fields (UHF-MRI) and different working voltages (spectral CT), respectively. Such advances require the parallel development of bimodal contrast agents (CAs) that are efficient under the new instrumental conditions. In this work, we have synthesized, through a precipitation reaction from a glycerol solution of the precursors, uniform barium dysprosium fluoride nanospheres with cubic fluorite structure, whose size was found to depend on the Ba/(Ba+Dy) ratio of the starting solution. Moreover, irrespective of the starting Ba/(Ba+Dy) ratio, the experimental Ba/(Ba+Dy) values were always lower than those used in the starting solutions. This result was assigned to a lower precipitation kinetics of barium fluoride compared to dysprosium fluoride, as inferred from the detailed analysis of the effect of reaction time on the chemical composition of the precipitates. A sample composed of 34 nm nanospheres with a Ba0.51Dy0.49F2.49 stoichiometry, showed a transversal relaxivity (r2) value of 147.11 mM-1·s-1 at 9.4 T and gave a high negative contrast in the phantom image. Likewise, it produced high X-ray attenuation in a large range of working voltages (from 80 KVp to 140 KVp), which can be attributed to the presence of different K-edge values, high Z elements (Ba and Dy) in the nanospheres. Finally, these nanospheres showed negligible cytotoxicity for different biocompatibility tests. Taken together, these results show that the reported nanoparticles (NPs) are excellent candidates as UHF MRI/Spectral CT bimodal imaging CAs.

File List: Fig 1 F1b: Size histogram of Ba40Dy60 NPs F1c: EDX spectrum of Ba40Dy60 NPs F1e: Size histogram of Ba51Dy49 NPs F1f: F1c: EDX spectrum of Ba51Dy49 NPs Fig 2 F2: Experimental XRD patterns of Ba40Dy60 and Ba51Dy49 samples Fig 3 F3b: XRD patterns of the precipitates obtained in the conditions used for the synthesis of Ba51Dy49 NPs but using different aging times F3c: Unit cell parameters and Ba/(Ba+Dy) ratio of the precipitates versus aging time Fig 4 F4a: DLS intensity curves of the Ba51Dy49 NPs suspended in water after different periods of time at rest F4b: FTIR spectrum of the Ba51Dy49 NPs Fig 5 F5g: Total number of cells per well after exposure to increasing concentration of NPs F5h: Percentage of dead cells after exposure to increasing concentration of Ba51Dy49 NPs. F5i: MTT assay of cells exposed to increasing concentration of Ba51Dy49 NPs Fig 6 F6a: 1/T2 values obtained in aqueous suspensions of Ba51Dy49 NPs at 9.4 T and 1.44 T versus Dy concentration of the suspensions Fig 7 F7b: X-ray attenuation at 80 kVp, in Hounsfield Units (HU), of aqueous suspensions containing Ba51Dy49 NPs and Iohexol, versus suspension concentration. F7c: X-ray attenuation, in HU, of aqueous suspensions containing 20.0 mg·mL-1 of Ba51Dy49 and DyF3 NPs, versus working voltage

Keywords

Originally assigned keywords

Contrast agent

UHF MRI

Spectral CT

Lanthanides

Nanoparticles

lanthanides

Corresponding MSL vocabulary keywords

spectral CT

MSL enriched keywords

Technique

imaging (3D)

computed tomography (CT)

spectral CT

minerals

halide minerals

fluorite

measured property

barium

dysprosium

equipment

x-ray spectrometer

energy-dispersive x-ray spectrometer

X-ray diffraction

MSL enriched sub domains i

microscopy and tomography

geochemistry

Source

https://digital.csic.es/handle/10261/357664

Source publisher

DIGITAL.CSIC

DOI

10.20350/digitalcsic/16267

Creators

González-Mancebo, Daniel

Becerro, Ana Isabel

Caro, Carlos

Gómez-González, Elisabet

García-Martín, María L.

Ocaña, Manuel

Contributors

Digital.CSIC

DataManager

Digital.CSIC

HostingInstitution

Citation

González-Mancebo, D., Becerro, A. I., Caro, C., Gómez-González, E., García-Martín, M. L., & Ocaña, M. (2024). Dataset - Nanoparticulated Bimodal Contrast Agent for Ultra-High-Field Magnetic Resonance Imaging and Spectral X-ray Computed Tomography [Data set]. DIGITAL.CSIC. https://doi.org/10.20350/DIGITALCSIC/16267

Dates

Accepted:

2024-05-21

Available:

2024-05-21

Issued:

2024

Language

en

Funding References

Funder name: This publication is part of the I + D + I Grants PID2021-122328OB-I00 and PID2020-118448RB-C21 funded by MCIN/AEI/10.13039/501100011033 and by “ERDF A way of making Europe”. This work was supported as well by Junta de Andalucía under grant no. P20_00182, co-financed by EU FEDER funds. High-field relaxivity measurements were performed at the ICTS “NANBIOSIS”, specifically in Unit 28 at the “Instituto de Investigación Biomédica de Málaga y Plataforma en Nanomedicina (IBIMA Plataforma BIONAND)”.

Rights

openAccess

https://creativecommons.org/licenses/by-nc/4.0/deed.es